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The Atarax brand name has been discontinued in the U. If generic versions of this product have been approved by the FDA, there may be generic equivalents available, Atarax Belgique. Atarax Description Hydroxyzine hydrochloride is designated chemically Commander Progesterone générique 1- p-chlorobenzhydryl Atarax Belgique 2-hydroxyethoxy -ethyl] piperazine dihydrochloride.
Inert ingredients for the tablets are: The 10 mg tablets also contain: The 25 mg tablets also contain: The 50 mg tablets also contain: The mg tablets also contain: The inert ingredients for the syrup are: Atarax – Clinical Pharmacology Atarax is unrelated chemically to the phenothiazines, reserpine, meprobamate, Atarax Belgique, or the benzodiazepines.
Atarax is not a cortical depressant, but its action may be due to a suppression of activity in certain key regions of Atarax Belgique subcortical area of the central nervous system.
Primary skeletal muscle relaxation has been demonstrated experimentally, Atarax Belgique. Bronchodilator activity, and anti- histaminic and analgesic effects have been demonstrated experimentally and confirmed clinically. An antiemetic effect, both by the apomorphine test and the veriloid test, has been demonstrated. Pharmacological and clinical studies indicate that hydroxyzine in therapeutic Atarax Belgique does not increase gastric secretion or acidity and in most cases has mild antisecretory activity.
- Primary skeletal muscle relaxation has been demonstrated experimentally.
- Central Nervous System Drowsiness is usually transitory and may disappear in a few days of continued therapy or upon reduction of the dose.
- Therefore when central nervous system depressants are administered concomitantly with hydroxyzine their dosage should be reduced.
Hydroxyzine is rapidly absorbed from the gastrointestinal tract and Atarax’s clinical effects are usually noted within 15 to 30 minutes after oral administration. Useful in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses, and in histamine-mediated pruritus, Atarax Belgique.
Atropine and other belladonna alkaloids are not affected by the drug. Hydroxyzine is not known to interfere Atarax Belgique the action of digitalis in any way and it may be used concurrently with this agent.
The effectiveness of hydroxyzine as an antianxiety agent for long term use, that is more than 4 months, Atarax Belgique, has not been assessed by systematic clinical studies. The physician should reassess periodically the usefulness of the drug for the individual patient. Contraindications Hydroxyzine, when administered to the pregnant mouse, Atarax Belgique, rat, and rabbit, induced fetal abnormalities in the Atarax Belgique and mouse at doses substantially above the human therapeutic range.
Clinical data in human beings are inadequate to establish safety in early pregnancy. Until such data are available, hydroxyzine is contraindicated in early pregnancy. Hydroxyzine is contraindicated for patients who have shown a previous hypersensitivity to it.
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Warnings Nursing Mothers It is not known whether this drug is excreted in human milk. Since many drugs are Atarax Belgique excreted, hydroxyzine should not be given to nursing mothers. For Tablets Only This product is manufactured with 1,1,1-trichloroethane, a substance which harms public health and the environment by destroying ozone in the upper atmosphere.
Therefore when central nervous system depressants are administered concomitantly with hydroxyzine their dosage should be reduced, Atarax Belgique. Since drowsiness may occur with use of this drug, patients should be warned of this possibility and cautioned against driving a car or operating dangerous machinery while taking Atarax.
Patients should be advised against the simultaneous use of other CNS depressant drugs, Atarax Belgique, and Atarax Belgique that the effect of alcohol may be increased. Geriatric Use A determination has not been made whether controlled clinical studies of Atarax included sufficient numbers of subjects aged 65 and over to define a difference in response from younger subjects.
Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient Atarax Belgique be cautious, usually starting at the low end of the Atarax Belgique range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.
Atarax – Clinical Pharmacology
The extent of renal excretion of Atarax has not been determined. Because elderly patients are more likely to have decreased renal function, Atarax Belgique, care should be taken in dose selections. Sedating drugs may cause confusion and over sedation in the elderly; elderly patients generally should be started on low doses of Atarax and observed closely.
Adverse Reactions Side effects reported with the administration of Atarax hydroxyzine hydrochloride are usually mild and transitory in nature, Atarax Belgique.
Central Nervous System Drowsiness is Atarax Belgique transitory and may disappear in a few days of continued therapy or upon reduction of the dose. Involuntary motor activity including rare instances of tremor and convulsions have been reported, usually with doses considerably higher than those recommended.
Clinically significant respiratory depression has not been reported at recommended doses. Overdosage The most common manifestation of Atarax overdosage is hypersedation, Atarax Belgique. As in the management of overdosage with any drug, it should be borne in mind that multiple agents may have been taken. If vomiting has not occurred spontaneously, Atarax Belgique, it should be induced.
Immediate gastric lavage is also recommended.
General supportive care, including frequent monitoring of the vital signs and close observation of the patient, is indicated. Do not use epinephrine as Atarax counteracts its pressor Atarax Belgique. There is no specific antidote. It is doubtful that Atarax Belgique would be of any value in the treatment of overdosage with hydroxyzine.
However, Atarax Belgique, if other agents such as barbiturates have been ingested concomitantly, hemodialysis may be indicated. There is no practical method to quantitate hydroxyzine in body fluids or tissue after its ingestion or administration.
DOSAGE For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested: For use in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses, and in histamine-mediated pruritus: As a sedative when used as a premedication and following general anesthesia: When treatment is initiated by the intramuscular route of administration, subsequent doses may be administered orally.
As with all medications, Atarax Belgique, the dosage should be adjusted according to the patient’s response Atarax Belgique therapy, Atarax Belgique.